アネリドと魚の前脳における保存された感覚神経分泌細胞タイプ: 視床下部の進化に関する洞察
Kristin Tessmar-Raible1, Florian Raible, Foteini Christodoulou
1Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69012 Heidelberg, Germany. kristin.tessmar@embl.de
Cell
|July 3, 2007
まとめ
神経分泌脳センターは,神経分泌脳センターです.
科学分野:
- 神経科学は神経科学である.
- 進化生物学の進化生物学について
- 発達生物学 発達生物学とは
背景:
- 神経分泌制御センターは,様々な動物群の前脳に不可欠です.
- これらの重要な脳中心の進化的起源は,ほとんど未調査のままである.
研究 の 目的:
- 神経分泌脳センターの保存された成分を特定し,系統遺伝的古代起源を示唆する.
- アネリドのヴァソトシン-ニューロフィシン発現ニューロンを比較するために Platynereis dumeriliiとゼブラフィッシュ.
主な方法:
- プラティネリスとゼブラフィッシュにおける血管新生性ニューロンの比較分析.
- マイクロRNA (miR-7) と転写因子発現 (nk2.1, rx, otp) の特徴づけ
- ゼブラフィッシュrx3がバソトシン-ニューロフィシン発現における役割を調査する.
主要な成果:
- miR-7と転写因子 (nk2.1,rx,otp) の共有発現は,両種の血管新生性ニューロンにおいて同じである.
- miR-7は,プラティネリスとゼブラフィッシュの共有RFamidergicニューロンをマークします.
- 血管新生性およびRFamidergicニューロンは,アネリドと魚の両方で感覚機能を発揮します.
結論:
- 保存された分子メカニズム (miR-7,転写因子) が,フィラ全体における神経分泌神経細胞のアイデンティティの基礎となっている.
- 双重感覚神経分泌細胞タイプは,バイラテリアの脳神経分泌センターの進化的起源として提案されています.
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