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システミック・ルプス・エリテマトサス (Systemic lupus erythematosus) は,左心室の質量の増加を予測する
Janice Pieretti1, Mary J Roman, Richard B Devereux
1Division of Cardiology, Weill Medical College of Cornell University and the Hospital for Special Surgery, New York, NY 10021, USA.
Circulation
|July 11, 2007
まとめ
システミック・ルプス・エリテマトーサス (SLE) は,他の心臓病がない場合でも,左心室 (LV) 質量および高縮の増加と関連しています. これは,炎症に関連した動脈硬化が,SLE患者における心臓の健康に影響を及ぼす可能性があることを示唆しています.
科学分野:
- 心臓病学 心臓病学
- レウマトロジーの病理学
- 血管生物学 血管生物学
背景:
- システミック・ルプス・エリテマトーサス (SLE) は,動脈硬化症と血管の硬化を加速することが知られている.
- 左心室 (LV) の構造と機能に対するSLEの影響は,弁または冠動脈疾患とは独立して,依然として不明確です.
研究 の 目的:
- 明らかに心血管疾患のない患者において,SLEがLVの構造と機能を変化させるかどうかを調査する.
- SLE,動脈硬化,およびLVリモデリングの関係を探求する.
主な方法:
- SLE患者 (n=173) と参照グループ (n=173) の年齢と性別を比較した比較.
- LVの構造と機能の評価のためのエコーカルディオグラフィー.
- 動脈硬化症の検出のための頸動脈超音波検査と,動脈の硬さを測定するための放射線平準化トノメトリー.
主要な成果:
- SLEの患者は,対照群と比較して,著しく高いLV質量 (P<0.001) を示し,LV縮のより高い流行率 (17.9%対6.4%,P<0.001) を示した.
- SLE患者におけるLV質量は,SLE自体 (P<0.001) と動脈硬化 (P<0.001) と独立して関連していました.
- 高血圧は,SLE患者におけるLV質量増加を悪化させた.
結論:
- システミック・ルプス・エリテマトーサス (Systemic lupus erythematosus) は,潜在的に炎症誘発性動脈硬化によって媒介される,LV質量増加の予測因子である.
- SLEにおける高濃度 LV 縮は,心疾患および心疾患の死亡率の増加に寄与する可能性があります.
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