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関連する概念動画

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Structure of Cadherins01:25

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

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Updated: Jun 13, 2026

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
06:45

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay

Published on: May 26, 2011

組み合わせたShcAドッキング相互作用は,組織形態変異の多様性を支持する.

W Rod Hardy1, Lingying Li, Zhi Wang

  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

Science (New York, N.Y.)
|July 14, 2007
PubMed
まとめ
この要約は機械生成です。

哺乳類のShcAドッキングタンパク質は,多様なシグナル伝達のために異なる相互作用ドメインを使用します. これらの組み合わせ相互作用は,心臓の発達と,運動行動を調節する感覚器官の形成の両方にとって極めて重要です.

さらに関連する動画

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
09:40

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes

Published on: September 28, 2018

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
08:58

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells

Published on: September 2, 2019

関連する実験動画

Last Updated: Jun 13, 2026

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
06:45

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay

Published on: May 26, 2011

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
09:40

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes

Published on: September 28, 2018

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
08:58

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells

Published on: September 2, 2019

科学分野:

  • 分子生物学は分子生物学である.
  • 発達生物学 発達生物学とは
  • 細胞シグナル伝達 細胞信号伝達

背景:

  • タンパク質とタンパク質の相互作用は,細胞の調節に不可欠です.
  • 哺乳類のShcAドッキングタンパク質は,フォスフォチロジン (pTyr) 結合 (PTB) とSrcホモロジー2 (SH2) ドメインを有する.
  • また,ShcAには,Grb2アダプタを結合する酸化チロシン-X-アスパラジン (pYXN) モチーフが含まれています.

研究 の 目的:

  • 哺乳類の発達におけるShcAドメインの独特な役割を調査する.
  • 異なる組織におけるShcAの機能の基礎となるシグナル伝達メカニズムを解明する.
  • 組み合わせドッキングの相互作用が組織形態変異にどのように貢献するかを理解する.

主な方法:

  • ShcAのシグナル伝達経路の系統遺伝分析.
  • マウスモデルを用いたインビボ研究.
  • 心筋細胞と筋肉の発達におけるShcAの役割の分析.

主要な成果:

  • Cardiomyocyte-expressed ShcAは,pYXNモチーフとは独立して,PTB依存の経路を通じて妊娠中期の心臓発育を指揮する.
  • pYXNモチーフは,PTBとSH2ドメインとともに,筋肉のスパインドル形成に不可欠です.
  • 筋肉は,運動行動を調節する重要な骨格筋の感覚器官です.

結論:

  • ShcAのドッキング相互作用の組み合わせの違いは,複数のシグナリングメカニズムを可能にします.
  • ShcAの機能的多様性は,組織形態変異の様々な側面をサポートしています.
  • ShcAのドメイン固有の機能を理解すると,開発プロセスに関する洞察が得られます.