Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Sketching microprotein portraits.

Protein science : a publication of the Protein Society·2026
Same author

Whole-body 3D kinematics of freely behaving <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2026
Same author

Pre-cheliceral region patterning in a spider provides new insights into the development and evolution of arthropod neurosecretory centres.

Open biology·2026
Same author

Rapidly evolving aphid gall effector proteins exhibit saposin-like folds.

bioRxiv : the preprint server for biology·2026
Same author

Evolutionary basis of male same-sex sexual behavior by multiple pheromone switches in Drosophila.

Current biology : CB·2026
Same author

Rewired gene interactions during evolution of the analia and genitalia in Drosophila.

Proceedings. Biological sciences·2026
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
Same journal

Dementia risk in middle-aged people linked to a blood protein.

Nature·2026
Same journal

Daily briefing: What's really happening with trust in science.

Nature·2026
関連記事をすべて見る

関連する実験動画

Updated: May 10, 2026

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
09:37

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

Published on: March 5, 2017

単一の遺伝子における複数のシス調節性変異による形態学的進化.

Alistair P McGregor1, Virginie Orgogozo, Isabelle Delon

  • 1Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA.

Nature
|July 17, 2007
PubMed
まとめ
この要約は機械生成です。

進化生物学は,種の違いを探求する. この研究は,Shavenbaby (svb) という単一の遺伝子で蓄積された小さな遺伝的変化が,Drosophila.の重要な形態学的進化を駆動することを明らかにしています.

さらに関連する動画

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
09:04

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells

Published on: September 25, 2019

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

関連する実験動画

Last Updated: May 10, 2026

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
09:37

Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

Published on: March 5, 2017

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
09:04

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells

Published on: September 25, 2019

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

科学分野:

  • 進化生物学の進化生物学について
  • 発達遺伝学 発達遺伝学
  • ゲノミクスゲノミクスとは

背景:

  • 種の違いの遺伝的根拠を理解することは,進化生物学における重要な問題である.
  • ネオ・ダーウィンの見解は,累積的な小さな遺伝的変化を示唆している一方,代替理論は,発達遺伝子の大きな効果の変異を提案している.
  • 種間の形態学的差異を引き起こす特定の遺伝子はほとんど特定されていません.

研究 の 目的:

  • ドロソフィラ種間のトリコームパターンの違いの遺伝的基盤を調査する.
  • シェーブンベイビー (svb) 遺伝子のシス調節性変化が,観察された形態学的差異の原因であるかどうかを判断する.
  • 単一の場所での複数の小効果変異が,種特有の現象型に寄与するという仮説を検証する.

主な方法:

  • ドロソフィラ・メラノガスターのsvb遺伝子の3つの増強剤を特定し,特徴づけました.
  • 遺伝子調節の変化を評価するために,ドロソフィラ・セセリアの同類強化剤の活性を比較した.
  • 原因となる遺伝領域を特定するために,高解像度の異種間遺伝子マッピングを行いました.
  • イントラジェニック再結合剤を用いた機能分析を行い,特定された強化剤の役割を検証した.

主要な成果:

  • D. melanogasterにおけるSVBの3つの異なる増強剤が特定され,内生的な発現パターンを再現した.
  • D. sechelliaからの同類の強化剤は,進化した現象型と一致する変化した表現パターンを示した.
  • 遺伝子マッピングにより,SVBの上流にある独立した領域が,これらの増強剤を重複させ,D. sechelliaのトリコームパターンのために集団的に必要であることを明らかにしました.
  • この研究は,SVBロカスにおける複数のシス調節変化が,形態学的差異に寄与することを示している.

結論:

  • D.セセリアのトリコームパターンの進化は,SVB遺伝子ロカス内の複数の小効果変異の蓄積によって引き起こされる.
  • この発見は,種間の有意な形態学的差異は,特定の遺伝子における多数の小さな遺伝的変異の累積的な効果から生じる可能性があるという考えを支持する.
  • この研究は,単一の遺伝子における微生物進化の変化が,マクロ生物進化の違いにつながる具体的な例を示しています.