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Updated: Jun 30, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

ペプチド-MHC複合体のT細胞受容体との低親和相互作用

K Matsui1, J J Boniface, P A Reay

  • 1Howard Hughes Medical Institute, Stanford, CA.

Science (New York, N.Y.)
|December 20, 1991
PubMed
まとめ

T細胞受容体 (TCRs) は,ペプチド-MHCリガンドを低 afinityで結合し,粘着が特定の抗原認識に先行することを示唆しています. これは,免疫反応とT細胞スキャン行動の理解に影響を与える.

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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

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