HIV-1の宿主コントロールの主要な決定因子の全ゲノム関連研究

Jacques Fellay1, Kevin V Shianna, Dongliang Ge

  • 1Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA.

Science (New York, N.Y.)
|July 21, 2007
PubMed
まとめ

遺伝的変異はHIV-1のコントロールに大きく影響し,ウイルス負荷の差異の15%を説明しています. 重要な遺伝因子には,ヒト白血球抗原 (HLA) アレルとRNAポリメラーゼIサブユニット遺伝子が含まれており,HIV疾患の進行を理解する上で極めて重要です.

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