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Updated: Jul 7, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
09:23

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

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脳のIRS2信号は,寿命と栄養素の恒常性を調整する

Akiko Taguchi1, Lynn M Wartschow, Morris F White

  • 1Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|July 21, 2007
PubMed
まとめ

インスリン受容体基板-2 (Irs2) のシグナル伝達をマウスで,特に脳で減少させることで,寿命が最大18%延長されました. この介入により,老齢マウスの代謝が改善され,酸化ストレスが軽減されました.

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