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Updated: Jun 25, 2026

Detection of Functional Matrix Metalloproteinases by Zymography
09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 9, 2010

トリプルヘリケール型移行状態アナログ:新種の選択的マトリックスメタルプロテインアース阻害剤

Janelle Lauer-Fields1, Keith Brew, John K Whitehead

  • 1Department of Chemistry and Biochemistry and College of Biomedical Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA.

Journal of the American Chemical Society
|August 4, 2007
PubMed
まとめ

研究者らは,マトリックス金属タンパク質酵素 (MMPs),特にMMP-2とMMP-9を標的とした新しいフォスフィナートトリプルヘリルペプチド阻害剤を開発しました. この新種のプロテアゼ阻害剤は,ゼラチナゼに対する高い親和性と選択性を示し,がん治療の有望な戦略を提供している.

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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides11:04

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