動脈動脈動脈腫の進行および脳卒中または一時的な性缺血性発作を有する患者の再発性血管イベント
Souvik Sen1, Alan Hinderliter, Pranab K Sen
1Department of Neurology, University of North Carolina, Chapel Hill, USA. SenS@neurology.unc.edu
Circulation
|August 9, 2007
まとめ
脳卒中またはTIAを患った患者の大動脈動脈腫の進行は,血管イベントの増加と関連しています. この発見は,これらの高リスクの個体における動脈動脈腫のモニタリングの重要性を強調しています.
科学分野:
- 心血管医学 心血管医学
- 神経学 神経学とは
- 血管生物学 血管生物学
背景:
- 大動脈 (AA) 動脈動脈腫は,脳血管疾患の既知の危険因子です.
- 脳卒中/TIA患者におけるAAアテロマの進行と,その後の血管疾患との関連は不明である.
研究 の 目的:
- 脳卒中または一時的な血栓性発作 (TIA) を経験した患者のAAアテロマの進行が再発性血管イベントと関連しているかどうかを調査する.
主な方法:
- 脳卒中/TIA,およびベースラインAAアテロマを患った167人の患者を,食道横断エコーカルジオグラム (TEE) で評価した.
- 117人の患者が12ヶ月のフォローアップTEEを受けた.
- AAアテロマの進行を評価し,患者さんの血管疾患の経過を観察した.
主要な成果:
- AAアテロマの進行は,12ヶ月間にわたって患者の28%で観察されました.
- 進行は,より高いホモシステインと中性粒子のレベルと関連していました.
- AAアテロマの進行を有する患者は,複合血管イベントの割合が著しく高かった (HR 5.8,P = 0.0002).
結論:
- 大動脈動脈動脈腫の進行は,脳卒中またはTIAの歴のある患者の再発性血管イベントと関連しています.
- この予備的な研究では,AAアテロマの進行をモニタリングすることは,脳卒中/TIA患者のリスク分層化にとって重要である可能性があることが示唆されています.
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