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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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ハンチントン病のユビキチン系における世界的な変化

Eric J Bennett1, Thomas A Shaler, Ben Woodman

  • 1Department of Biological Sciences, Stanford University, Stanford, California 94305, USA.

Nature
|August 10, 2007
PubMed
まとめ

ハンチントン病 (Huntington's disease,HD) は,ポリユビキチン鎖が脳に蓄積され,ユビキチン-プロテアソーム系 (UPS) 機能の障害を示唆する. この機能不全は,マウスモデルとヒト患者の両方で,HD病理学の早期かつ一貫した特徴です.

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