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Updated: May 8, 2026

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Published on: June 28, 2018

IRF8結合プロモーターの変異体とAIRE制御CHRNA1は,胸腺における乱交的発現を制御する

Matthieu Giraud1, Richard Taubert, Claire Vandiedonck

  • 1Inserm, U580, 75015 Paris, France.

Nature
|August 10, 2007
PubMed
まとめ

新種のCHRNA1遺伝子プロモーター変異体は,IRF8結合を阻害することで,耐性を破壊し,早期発症の自己免疫性ミアステニア・グラビスを引き起こす. これは,自己抗原発現と自己耐性を調節するAIREとインターフェロン経路を強調しています.

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