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Updated: Jul 9, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

LeuT-デシプラミン構造は,抗うつ薬が神経伝達物質の再吸収をブロックする方法を明らかにしています

Zheng Zhou1, Juan Zhen, Nathan K Karpowich

  • 1Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

Science (New York, N.Y.)
|August 11, 2007
PubMed
まとめ

デシプラミンなどの三環抗うつ剤は,神経伝達物質のトランスポーターに結合することによって,神経伝達物質のトランスポーターをブロックし,構造の変化と基板輸送を防止します. このメカニズムは,人間のセロトニンとドーパミントランスポーターに保存されている可能性が高い.

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Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

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