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Updated: Jul 6, 2026

In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions
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DNAポリメラーゼベータ触媒:異なるメカニズムは可能ですか?

Ian L Alberts1, Yanli Wang, Tamar Schlick

  • 1Department of Chemistry and Courant Institute of Mathematical Sciences, 251 Mercer Street, New York University, New York, New York 10012, USA.

Journal of the American Chemical Society
|August 19, 2007
PubMed
まとめ

研究者は,QM/MMを用いてDNAポリメラーゼβ (ポリββ) のメカニズムを研究した. ヌクレオチド移転の最も可能性の高い経路は,水への初期デプロトネーションを含み,不一致の塩基ペアに対するより高いエネルギーバリアがあり,ポリメラーゼの忠誠性を説明します.

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