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Updated: Jul 13, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

古代のタンパク質の結晶構造:構造的エピスタシスによる進化

Eric A Ortlund1, Jamie T Bridgham, Matthew R Redinbo

  • 1Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.

Science (New York, N.Y.)
|August 19, 2007
PubMed
まとめ

研究者らは,脊椎動物のグルココルチコイド (GR) およびミネラルコルチコイド (MR) 受容体への古代のタンパク質前駆体を復活させました. 構造分析により,GRを牽引する重要な変異が明らかになった.

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