日々のアンフェタミンの多重投与:行動的および神経化学的変化
Science (New York, N.Y.)
|February 22, 1980
まとめ
ネズミにアンフェタミンを繰り返し注射すると,より速く,より強いステレオタイプ反応が生じる. このアンフェタミンに対する感受性の向上は,薬物休暇の後にさえも持続し,アンフェタミンによる精神病の発症の役割を示唆しています.
科学分野:
- 神経科学は神経科学である.
- 薬理学 薬理学とは
- 行動科学は,行動科学である.
背景:
- 繰り返しアンフェタミンを投与すると,行動反応が変化する可能性があります.
- これらの変化を理解することは,薬物依存症と精神病を理解するために不可欠です.
研究 の 目的:
- ネズミの行動反応に対するアンフェタミンの繰り返し投与の長期的な効果を調査する.
- 禁断期間を経てアンフェタミンに対する感受性の上昇が持続するかどうかを判断する.
主な方法:
- ネズミは5日間,4時間ごとにアンフェタミン注射 (2.5 mg/kg) を毎日受けた.
- ステレオタイプと多動性の発症,大きさ,オフセットを含む行動パラメータが測定されました.
- モノアミンの濃度,アンフェタミン濃度,チロシンヒドロキシラーゼの活性が評価されました.
主要な成果:
- 繰り返されたアンフェタミン注射は,ステレオタイプの発症速度と大きさの漸進的な増加につながった.
- 治療中にステレオタイプと過活動性のオフセット時間は著しく短縮されました.
- 強化されたステレオタイプの発症は,治療終了後8日後に持続し,オフセット時間はベースラインに戻りました.
結論:
- 繰り返しアンフェタミンに曝露すると,その効果に対する持続的な過敏性が生じます.
- この持続的な反応性の向上は,アンフェタミン精神病の発症に寄与する要因である可能性があります.
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