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冬季に発生する動物性がん 冬季に発生する動物性がん フローダー,Pseudopleuronectes americanus
まとめ
ネオプラズマはボストン港の冬 (Pseudopleuronectes americanus) で発見されました. コランジオカルシノーマと肝臓カルシノーマを含むこれらの肝臓腫瘍は,発がん物質に曝露したネズミで見られる腫瘍に似ている.
科学分野:
- マリン・バイオロジーの海洋生物学
- イクチオロジー イクチオロジー
- 環境毒性学 環境毒性学
背景:
- 冬 (Pseudopleuronectes americanus) は,米国北東部で商業的に重要な魚種である.
- 以前の研究では,ボストン港の海洋生物の健康状態について懸念を喚起しました.
研究 の 目的:
- ボストン・ハーバーの冬のフローダーにおける肝臓腫瘍の有病率を調査する.
- 観察された肝臓病変の種類を特徴付け,知られた発がん剤誘発性病変と比較する.
主な方法:
- 冬のフローダーから得られた肝臓組織のヒストオパソロジック検査.
- ボストン港から採取した200種類の魚のサンプルを分析した.
主要な成果:
- 検査された冬のフローダーでは,高頻度の腫瘍が検出されました.
- コランジオカルシノーマと肝がんとして識別された病変は,200匹の魚のうち16匹に存在していました.
- 観察された病変は,歯類のモデルにおける発がん剤によって誘発された病変と形態学的に類似していた.
結論:
- ボストン・ハーバーの冬の魚は,肝臓腫瘍の有意な発生率を示しています.
- この調査結果は,ボストン港の環境で発がん性物質に潜在的に曝露していることを示唆している.
- 冬のの個体群に影響を与える特定の発がん物質とその源を特定するために,さらなる研究が必要である.
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