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Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
Proofreading01:31

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Variance01:15

Variance

The deviations show how spread out the data are about the mean. A positive deviation occurs when the data value exceeds the mean, whereas a negative deviation occurs when the data value is less than the mean. If the deviations are added, the sum is always zero. So one cannot simply add the deviations to get the data spread. By squaring the deviations, the numbers are made positive; thus, their sum will also be positive.The standard deviation measures the spread in the same units as the data.

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関連する実験動画

Updated: Jul 6, 2026

Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

Erratum Erratum エラトゥーム エラトゥーム

    Science (New York, N.Y.)
    |February 8, 1991
    PubMed
    まとめ

    アルセンやラドンなどの天然の毒素は,しばしば高濃度で発見され,歴史的に見過ごされていました. 研究の取り組みは,産業用汚染物質の痕跡に焦点を当て,重要な自然発がん物質を無視した.

    科学分野:

    • 環境科学 環境科学
    • 毒理学 毒理学 毒理学
    • 公衆衛生は公衆衛生である.

    背景:

    • 産業汚染物質に関する懸念は,しばしば自然に発生する毒素を覆う.
    • 水中の天然ヒ素と室内の空気中のラドンの高いレベルは,さまざまな場所で特定されています.
    • 歴史的な研究努力は,自然環境の危険性よりも,工業的な汚染物質に不均衡に重点を置いています.

    研究 の 目的:

    • 自然汚染物質と産業汚染物質の相対的な重要性に関する以前の記述を訂正し,明確にする.
    • 環境衛生研究における重要な自然発がん物質の歴史的無視を強調する.
    • 環境リスクの評価においてバランスの取れたアプローチの必要性を強調する.

    主な方法:

    • 出版された科学的通信のレビューと訂正.
    • 環境毒性学における過去の研究優先事項の分析.
    • 自然および産業汚染物質に関連する危険因子の比較評価.

    主要な成果:

    • 環境毒素に関する公開された手紙の特定訂正を特定しました.
    • 高い罹患率にもかかわらず,天然のヒ素とラドンが無視されていたことを強調した.
    • 工業汚染物質の微小なレベルに歴史的な焦点を当てていることを実証しました.

    さらに関連する動画

    Development of an Experimental Setup for the Measurement of the Coefficient of Restitution under Vacuum Conditions
    07:49

    Development of an Experimental Setup for the Measurement of the Coefficient of Restitution under Vacuum Conditions

    Published on: March 29, 2016

    Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
    05:46

    Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

    Published on: September 20, 2024

    関連する実験動画

    Last Updated: Jul 6, 2026

    Molecular Evolution of the Tre Recombinase
    12:02

    Molecular Evolution of the Tre Recombinase

    Published on: May 29, 2008

    Development of an Experimental Setup for the Measurement of the Coefficient of Restitution under Vacuum Conditions
    07:49

    Development of an Experimental Setup for the Measurement of the Coefficient of Restitution under Vacuum Conditions

    Published on: March 29, 2016

    Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
    05:46

    Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

    Published on: September 20, 2024

    結論:

    • アルセンやラドンなどの天然の毒素は,環境の健康に重大なリスクをもたらす.
    • 高レベルの自然環境的危険に対処するために,研究優先事項の再評価が必要である.
    • 自然汚染物質と産業汚染物質の両方をバランスよく考慮することは,効果的な公衆衛生戦略にとって極めて重要です.