犬におけるストレプトマイシンの吸収と排泄に関する予備的な研究
まとめ
犬の親腸内ストレプトミシン投与により,血中濃度が高く,尿路で有意な分泌が達成されました. 口服用ストレプトマイシンは吸収が最小で,尿路の回復が低かったため,生物学的利用性が低いことが示されました.
科学分野:
- 薬理学 薬理学とは
- 獣医医学 獣医医学は,獣医医学というものです.
- 薬物の代謝について
背景:
- ストレプトマイシンは,細菌感染症の治療に不可欠な抗生物質です.
- 薬理学的なプロフィールを理解することは,効果的な治療用途に不可欠です.
研究 の 目的:
- 静脈内,肌内,および口服投与後の犬におけるストレプトマイシンの薬理 Untuak manilai farmakokinetika.
- 犬の被験者におけるストレプトマイシンの吸収,分布,排泄パターンを決定する.
主な方法:
- 14匹の健康な犬は,静脈内,筋肉内,または口服でストレプトマイシンを投与された.
- 投与量は10万から420万ユニットであった.
- 血液と尿のサンプルを分析して,時間の経過とともにストレプトミシン濃度を調べました.
主要な成果:
- 親体投与 (IVおよびIM) は,初期に高血中ストレプトミシン濃度をもたらした.
- 麻酔投与後のストレプトマイシンの尿による排泄量は23~65%であった.
- 経口ストレプトミシン投与では,プラズマ検出は無視され,尿では3.9%までしか検出されなかった.
結論:
- ストレプトマイシンの静脈内および筋肉内投与は,犬の血中濃度の維持に匹敵する結果をもたらします.
- 口服用ストレプトマイシンは,犬の生物学的利用性が低く,消化器系からの吸収が限られている.
- ストレプトマイシンは主に犬の腎臓分泌で排出されます.
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