関連する実験動画

Updated: Jul 12, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

ソマティックハイパーミューテーション中の変異のストランドバイアス型拡散

Shyam Unniraman1, David G Schatz

  • 1Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA.

Science (New York, N.Y.)
|September 1, 2007
PubMed
まとめ

抗体遺伝子のソマティック・ハイパーミューテーション (SHM) の多様性は,活性化誘発デアミナーゼ (AID) がサイトシンをデアミナーすることによって開始されます. 不一致修復機構は,上鎖のウラシルを標的とし,抗体応答中にSHMを促進します.

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