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イーストのプリオン菌株の変異体の構造的基礎

Brandon H Toyama1, Mark J S Kelly, John D Gross

  • 1Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco and California Institute for Quantitative Biomedical Research, San Francisco, California 94158-2542, USA.

Nature
|September 4, 2007
PubMed
まとめ

イーストSup35,Sc4およびSc37のようなプリオン株は,明確な構造を示しています. プリオンタンパク質のこれらの大規模な構造的差異は,その変化する安定性と複製を説明し,疾患の現象型に影響を与えます.

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