Tellina alternata (Bivalvia) の神経ヘモグロビンから延長された酸素供給
Science (New York, N.Y.)
|April 4, 1986
まとめ
Tellina alternataの神経ヘモグロビンは酸素を貯蔵し,無酸素期間の神経活動を維持する. この貯蔵された酸素は,顕微鏡の組織内の有酸素機能を長期間サポートします.
科学分野:
- 神経生物学 神経生物学とは
- マリン・バイオロジー マリン・バイオロジー
- バイオケミストリー バイオケミストリー
背景:
- 双の軟体動物は独特のヘモグロビンシステムを備えています.
- 酸素ホメオスタシスにおけるニューラルヘモグロビンの役割は完全に理解されていません.
- Tellina alternataは,神経系内で独特のヘモグロビン局所化を示しています.
研究 の 目的:
- Tellina alternataの神経におけるヘモグロビンの機能的重要性を調査するために.
- 麻酔状態下での興奮性の維持に神経ヘモグロビンの貢献を決定する.
主な方法:
- Tellina alternataの切断された神経は,純粋な窒素 (無酸素) に曝された.
- ヘモグロビンの酸素排出時間を測定した.
- 神経刺激性は,脱酸素化中にモニタリングされました.
- ヘモグロビンの酸素結合機能と神経活動に対する一酸化炭素の影響を評価した.
主要な成果:
- Tellinaのヘモグロビンの交代神経は,無酸素下で酸素を排出するのに30分かかりました.
- 神経刺激性は,ヘモグロビン脱酸素化が完了するまでのみ維持された.
- ヘモグロビンの酸素結合機能を一酸化炭素で廃止すると,酸素が除去されると神経刺激性が急速に停止する.
結論:
- 神経のヘモグロビンは酸素貯蔵庫として作用し,無酸素現象の間,顕微鏡の神経組織内の有酸素活動を維持します.
- このヘモグロビンに依存する酸素供給は,長時間酸素不足下で神経刺激性を維持するために不可欠です.
- この発見は,双弁神経系における酸素管理のための特殊な適応を強調している.
関連する概念動画
01:27Oxygen Transport in the Blood
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
01:23Hypoxia
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
01:24Hemoglobin
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
01:29Blood and Nerve Supply to the Bones
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...