関連する実験動画
Updated: Jul 12, 2026
12:19
Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
複雑な組織におけるg2における細胞停止を促すホルモンの化学的特徴
Science (New York, N.Y.)
|March 16, 1979
まとめ
研究者らはトライゴネリン (N-メチルニコチン酸) を,豆植物におけるG2段階の細胞循環停止因子として特定した. これは,複雑な植物および動物組織におけるホルモン調節細胞停止の化学的同定を初めて示している.
科学分野:
- 植物生理学 植物生理学
- 細胞生物学 細胞生物学
- バイオケミストリー バイオケミストリー
背景:
- 細胞循環の調節は,生物の発達に極めて重要です.
- 植物ホルモンは,成長と発達において重要な役割を果たします.
- 細胞サイクル制御メカニズムを理解することは,植物科学にとって不可欠です.
研究 の 目的:
- Pisum sativum cotyledons.のG2相成長阻害因子を分離し,特定する.
- 特定された因子の化学的同一性を決定する.
- 複雑な組織における潜在的なホルモンとしての役割を調査する.
主な方法:
- Pisum sativum cotyledons.からG2因子を分離した.
- 要素の構造を決定するための化学的識別技術.
- G2段階における成長停止を確認するための細胞サイクル分析.
主要な成果:
- G2ファクターは, pea cotyledon.から成功裏に分離されました.
- 孤立した因子はトリゴネリン (N-メチルニコチン酸) と特定されました.
- トリゴネリンは,細胞循環のG2段階の細胞成長を止める能力を示しました.
結論:
- トリゴネリンは,Pisum sativumの細胞サイクル進行を調節する重要な要因です.
- これは,複雑な植物および動物組織における細胞サイクル停止を引き起こすホルモンの最初の化学的識別である.
- トリゴネリン (Trigonelline) は,植物性細胞循環調節剤の新種のクラスである.
関連する概念動画
01:23Negative Regulator Molecules
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
01:28The Cell Cycle Control System
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
01:27Molecular Factors Affecting Cell Division
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
01:45Positive Regulator Molecules
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
02:39Positive Regulator Molecules
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
02:34Inhibition of Cdk Activity
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...