ペニシリンGとKの不活性化は,肝臓と腎臓によって行われます
まとめ
ペニシリンKの不活性化は,腎臓が縛られたウサギではより速くなります. 肝臓と腎臓の両方の切片はペニシリンKを無効化し,腎臓組織はより高い活性を示します. このペニシリンの無活性化は,有酸素および無酸素の両方の条件下で発生します.
科学分野:
- 薬理学 薬理学とは
- バイオケミストリー バイオケミストリー
- 腎臓生理学 腎臓生理学
背景:
- ペニシリンKは in vivo で無活性化されます.
- ペニシリンの代謝に責任を負う臓器を理解することは,薬剤の有効性にとって極めて重要です.
- 以前の研究では,薬剤の無活性化に腎臓と肝臓の関与が示唆されています.
研究 の 目的:
- ウサギにおけるペニシリンK不活性化の速度と部位を調査する.
- ペニシリンKの代謝における肝臓と腎臓の組織の役割を決定する.
- ペニシリンKの不活性化に酸素の供給が与える影響を評価する.
主な方法:
- ペニシリンKの無活性化率の比較 整体 vs 消化された腎臓が絡み合っているウサギ.
- 隔離されたウサギの肝臓と腎臓のスライスでペニシリンKのインキュベーション.
- アエロビック条件とアエロビック条件の両方で無活性化の評価.
主要な成果:
- ペニシリンKの不活性化は,内臓を抜いた製剤と比較して,腎臓が絡み合っているウサギでは著しくより迅速であった.
- 生き残った肝臓と腎臓の両方の切片は,ペニシリンKを無効化する能力を示した.
- 腎臓の切片は,肝臓の切片よりもペニシリンKを無効化する能力が大きいことを示した.
- 不活性化は,酸素の可用性 (有酸素および無酸素条件) にかかわらず発生しました.
結論:
- 腎臓は,ウサギにおけるペニシリンKの急速な無効化に重要な役割を果たします.
- 腎臓と肝臓の両方の組織はペニシリンKの代謝に寄与する.
- これらの組織によるペニシリンKの不活性化は,有酸素代謝に厳密に依存するものではありません.
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