サイクロプロパンおよびエステル群が欠けている化合物のピレトロイドのような生物学的活性
Science (New York, N.Y.)
|September 13, 1968
まとめ
新しい殺虫剤化合物,ケトンアナログおよび新しいエステルは,ピレトロイドのような活性を示します. これらの化合物は,ピペロニルボトキシドと相乗効果を示し,アレトリンに似た神経興奮性をブロックします.
科学分野:
- 有機化学 オーガニック・ケミストリー
- 昆虫駆除剤の開発について
- 神経毒理学 神経毒理学について
背景:
- ピレトロイドは,その有効性と哺乳類に対する毒性が比較的低いことで知られている主要な殺虫剤のクラスです.
- ピレトロイドの殺虫作用は,しばしば特定の化学構造,特にサイクロプロパンカルボキシル酸のエステルと関連付けられています.
- ピペロニルブトキシドは,代謝解毒を阻害することによって,特定の殺虫剤の有効性を高めるために使用される一般的なシネジストです.
研究 の 目的:
- ピレトロイドのような活性に対する新しい殺虫剤化合物を調査する.
- これらの化合物がピペロニルブト酸化物と相乗効果を示すかどうかを判断する.
- アレトリンと比較して神経興奮阻害のメカニズムを解明する.
主な方法:
- アレトリンのケトンアナログの合成: 1-(4-アレトロニル) -アセチル-2,2-ジメチル-3-イソブテンイルサイクロプロパン.
- 5-ベンジル-3フーリルメタノールのエステル化により,様々な炭酸酸: 2,2,3,3-テトラメチルcyclopropanecarboxylic 酸, 2,2,3,3-テトラメチルziridinecarboxylic 酸,およびN,N-diisopropylcarbamic 酸.
- 昆虫駆除作用の評価,ピペロニルブトキシドとのシネージズム,および神経興奮性の阻害.
主要な成果:
- 合成されたケトンアナログと新しいエステルは,殺虫剤の性質を示した.
- これらの化合物は,ピペロニルブトキシドとの相乗効果を示し,従来のピレトロイドと代謝経路を共有していることを示した.
- これらの化合物は,ピレトロイド殺虫剤アレトリンに似たメカニズムで神経の興奮を阻害した.
結論:
- ピレトロイドのような殺虫剤の活性性は,サイクロプロパンカルボキシル酸のエステルに限定されていません.
- ケトンアナログや異なるエステルタイプなどの新しい化学的支架は,強力な殺虫剤特性を有することがあります.
- これらの発見は,昆虫駆除における潜在的な応用を持つ化合物の構造的多様性を拡大します.
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