トウモロコシ油とラノリンのペニシリンの口服投与

D Perlstein, R G Kluener, A J Liebmann

Science (New York, N.Y.)

|July 20, 1945

まとめ

トウモロコシ油とラノリンのサスペンションに含まれるペニシリンの経口投与は,体内の存在を大幅に延長します. この方法は,ペニシリンの濃度を最大42時間増加させ,塩溶液よりも5倍の改善を提供します.

科学分野:

薬理学薬理学とは
薬物の配送システムです.

背景:

ペニシリンの経口投与は,細菌感染を治療する一般的な方法である.
経口投与後の血液中の治療性ペニシリンのレベルを維持することは,迅速な排泄により困難である可能性があります.

研究の目的:

トウモロコシ油とラノリンの混合物でペニシリンをサスペンションにすることで,その全身維持に及ぼす影響を調査する.
この新しいサスペンションを使用したペニシリン濃度の持続時間と回復を,従来の塩分溶液と比較するために.

主な方法:

ペニシリンは,コーンオイルとラノリンを1:1の混合液に溶かして,経口投与された.
尿のバイオアッセイは,時間の経過とともに被験者のペニシリン濃度を決定するために使用されました.
結果は,過去のデータや,塩溶液でペニシリンを投与した対照群と比較した.

主要な成果:

トウモロコシ油とラノリンで懸浮したペニシリンは,摂取後24~42時間,体内で測定可能なレベルを維持した.
ペニシリンの回収量は,塩溶液での投与と比較して約5倍でした.
これは,オイル・ラノリン媒介体によるペニシリンの長期にわたる全身的可用性を示している.

結論:

トウモロコシ油とラノリンの混合物の中にペニシリンをサスペンドすると,効果的に体内の治療的存在を延長します.
この製剤はペニシリンの生物学的利用可能性と作用期間を高め,治療効果を潜在的に改善します.
この発見は,ペニシリンの経口投与のための有望な代替手段を示唆しています.

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