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関連する概念動画

Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...

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関連する実験動画

Updated: Jul 11, 2026

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

ボリウム酸塩が siderophores に結合する: 構造と安定性

Wesley R Harris1, Shady A Amin, Frithjof C Küpper

  • 1Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182-1030, USA.

Journal of the American Chemical Society
|September 14, 2007
PubMed
まとめ

特定のシデロホルスは,鉄だけでなく,ボロンも結合する. 特定の化学グループに依存するこの予期せぬ親和性は,海洋細胞のシグナル伝達とボロン吸収における役割を示唆しています.

科学分野:

  • バイオケミストリー バイオケミストリー
  • 環境化学 環境化学
  • 微生物学 微生物学とは

背景:

  • シドロフォアは,細菌による鉄のケレーターです.
  • ボロンは海洋環境において不可欠である.
  • ボロンの生物学的役割は完全に理解されていません.

研究 の 目的:

  • シデロフォール-ボロン相互作用を調査する.
  • ボロン結合の構造要求を決定する.
  • ボロン-シドロフォア複合体の潜在的な生物学的機能を調査する.

主な方法:

  • 電気スプレーイオン化質量スペクトロメトリー (ESI-MS).
  • 多核核磁共振 (NMR) スペクトロスコーピー. 多核核磁共振 (NMR) スペクトロスコーピー. 多核核磁共振 (NMR) スペクトロスコーピー. 多核核磁共振 (NMR) スペクトロスコーピー. 多核核磁共振 (NMR) スペクトロスコーピー.
  • 密度関数理論 (DFT) による計算.
  • ボロン結合定数の測定. ボロン結合定数の測定.

主要な成果:

  • シドロフォアには,シトラートまたはカテコラート群があり,ボロンと結合する.

さらに関連する動画

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
05:35

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Published on: January 17, 2020

関連する実験動画

Last Updated: Jul 11, 2026

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
05:35

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Published on: January 17, 2020

  • ビブリオフェリン,リゾフェリン,ペトロバクチンを含むボロン複合体の特徴.
  • 海洋のpHで測定された重要なボロン結合定数.
  • ボロンの結合は,独特のシデロフォール形状を誘導する.

    • 結論:

    • 特定のシデロホルスは,予期せぬボロン親和性を示す.
    • ボロン-シドロフォア複合体は,海洋環境で形成されることがあります.
    • 生物学的ボロン吸収と細胞シグナル伝達における潜在的な役割が仮説化されている.
    • 形状の変化により,鉄とボロンの結合作用を区別することができる.