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ターナー症候群における大動脈の膨張と解剖
Lea Ann Matura1, Vincent B Ho, Douglas R Rosing
1Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Circulation
|September 19, 2007
まとめ
ターナー症候群 (TS) の女性は,大動脈解剖のリスクが高くなります. 動脈大動脈サイズ指数>2.0cm/m2は,大動脈の大幅な膨張を示し,解剖のリスクを注意深く監視する必要があります.
科学分野:
- 心血管医学 心血管医学
- 遺伝学 遺伝学とは
- エンドクリノロジー エンドクリノロジー
背景:
- ターナー症候群 (TS) は,若い女性において大動脈解剖のリスクが高いと関連しています.
- TSにおける大動脈の膨張と急性大動脈解剖の関係については,まだはっきりしていない.
- TS患者における大動脈の悪化を予測する要因については,さらなる調査が必要である.
研究 の 目的:
- ターナー症候群の女性において,大動脈の膨張が大動脈解剖に先行するかどうかを調査する.
- TS.における迫り来る大動脈事件を予測する特定の大動脈直径測定を特定する.
- TSにおける心血管リスク管理における大動脈サイズ指数の有用性を評価する.
主な方法:
- 166人の成人女性TS患者と26人の健康な女性対照群の遡及的分析.
- MRIで測定された上昇および下降大動脈直径は,体表面積 (大動脈サイズ指数) に正常化されています.
- 大動脈解剖事件を記録するために,約3年間の追跡調査が行われました.
主要な成果:
- TSの女性では,絶対的な大動脈直径は類似していたが,対照群と比較して,大動脈サイズ指数は著しく高かった.
- 32%のTS女性では,大動脈サイズ指数値が95パーセント以上 (>2.0cm/m2) であった.
- 3人のTS女性は大動脈解剖を経験し,すべて上昇大動脈直径> 3.7cmと大動脈サイズインデックス> 2.5cm/m2.
結論:
- TSの若い女性では,大動脈解剖のリスクが著しく増加しています.
- 大動脈サイズ指数は,体長が低いため,TSの膨張を検出するための好ましい測定法です.
- 動脈大動脈サイズ指数>2.0cm/m2は,心臓血管の緊密な監視を保証する;>2.5cm/m2は,解剖のリスクが最も高いことを示します.
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