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Updated: Jul 11, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

N2-(1-カルボキシエチル) - 2'-デオキシグアノシンを含むオリゴデオキシリボヌクレオチドのステレオ特異的合成と特徴づけ

Huachuan Cao1, Yong Jiang, Yinsheng Wang

  • 1Department of Chemistry, University of California, Riverside, California 92521-0403, USA.

Journal of the American Chemical Society
|September 20, 2007
PubMed
まとめ

メチルグリオキサルは,N2-(1-カルボキシエチル) - 2'-デオキシグアノシン (N2-CEdG) のようなDNAアダクトを形成する. この研究では,DNAでN2-CEdGを合成し,複製を阻害し,ポリメラーゼエラーを引き起こすことを発見しました.

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