アポリポプロテインE遺伝子型と脂質レベル,冠動脈リスクとの関連
Anna M Bennet1, Emanuele Di Angelantonio, Zheng Ye
1Department of Public Health and Primary Care, University of Cambridge, Cambridge, England.
JAMA
|September 20, 2007
まとめ
アポリポプロテインE (apoE) ゲノタイプは,脂質レベルと冠動脈リスクに影響します. apoE epsilon2/epsilon2遺伝子型を持つ人はLDL-Cが低く,epsilon4キャリアは冠動脈疾患のリスクがわずかに増加しています.
科学分野:
- 遺伝学と心血管疾患の研究.
- 脂質代謝と心血管の健康について.
- 集団遺伝学と疾病リスク評価.
背景:
- アポリポプロテインE (apoE) 遺伝子型と冠動脈疾患に関する以前のレビューは,バイアスに弱い小さな研究によって制限されていました.
- ApoEの遺伝子型,脂質レベル,冠動脈リスクとの関連を明らかにするために,包括的な再評価が必要である.
研究 の 目的:
- アポリポプロテインE (apoE) ゲノタイプと循環中の脂質レベルとの関連性を再評価する更新されたメタ分析を実施する.
- apoEゲノタイプと全般的な冠動脈リスクとの関係を評価する.
主な方法:
- 複数のデータベース (MEDLINE,EMBASE,BIOSISなど) の既刊未刊の研究を統合した更新されたメタ分析が行われました. 1970年から2007年までの間,
- 脂質レベルに関する82件の研究 (86,067人の参加者) と冠動脈アウトカムに関する121件の研究 (37,850例,82,727人の対照群) を含め,より大きな研究を優先した.
- 遺伝子型頻度,脂質レベル,冠動脈のアウトカム,および特徴に関するデータは,2人の研究者によって独立して抽出されました.
主要な成果:
- アポリポプロテインE (apoE) ゲノタイプは,低密度リポプロテインコレステロール (LDL-C) と冠動脈リスクとのほぼ線形的な関係を示しました.
- エプシロン2/エプシロン2遺伝子型を持つ個人は,エプシロン4/エプシロン4キャリアと比較して,著しく低いLDL-Cを持っていた.
- エプシロン3/エプシロン3遺伝子型と比較して,apoEエプシロン2キャリアは冠動脈疾患 (0.80) の確率比が低下し,エプシロン4キャリアは確率比 (1.06) がわずかに増加した.
結論:
- アポリポプロテインE (apoE) の遺伝子型は,LDL-Cレベルと冠動脈疾患のリスクの両方とほぼ線形的な関連性を示しています.
- apoE epsilon2アレルを持つ個人は,冠動脈疾患のリスクが20%低く,epsilon4キャリアはepsilon3/epsilon3個人に比べてリスクがわずかに高い.
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