オメガ3多飽和脂肪酸の摂取量と1型糖尿病のリスクが高い小児における小島型自己免疫
Jill M Norris1, Xiang Yin, Molly M Lamb
1Department of Preventive Medicine and Biostatistics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA. jill.norris@uchsc.edu
JAMA
|September 27, 2007
まとめ
オメガ3脂肪酸の摂取は,遺伝的に1型糖尿病に罹患する傾向のある小島型自己免疫 (IA) のリスクの低下と関連しています. この発見は,早期糖尿病の発症におけるオメガ3の保護的役割を裏付けている.
科学分野:
- 免疫学 免疫学とは
- 栄養科学とは,栄養科学である.
- 小児科は小児科です.
背景:
- 以前の研究では,トード肝油が1型糖尿病のリスクを減らす可能性があることが示唆されています.
- オメガ3およびオメガ6脂肪酸の島根自己免疫 (IA) における役割を調査することは,1型糖尿病 (T1D) の発症を理解するために極めて重要です.
研究 の 目的:
- オメガ3およびオメガ6脂肪酸の摂取が,リスクの高い子供における小島型自己免疫 (IA) の発症に影響を与えるかどうかを判断する.
- ポリ不飽和脂肪酸の摂取とIAの発達との関連を評価する.
主な方法:
- 縦断的な観察研究 (DAISY) では,T1Dのリスクの高い1770人の子どもを追跡した.
- ポリ不飽和脂肪酸の食事摂取量は,1歳から記録されました.
- ケースコホート研究では,赤血球膜の脂肪酸含有量に基づいてIAリスクを調査した.
主要な成果:
- 58人の子供たちがIAを発症した.
- オメガ3脂肪酸の摂取量の増加は,混同要因を調整した後でも,AIリスク (HR,0.45;P = .04) と反転的に関連していました.
- また,赤血球膜のオメガ3脂肪酸含有量は,IAリスクと逆の関連性を示した (HR, 0.63; P = .03).
結論:
- 食中のオメガ3脂肪酸の摂取は,1型糖尿病の遺伝的傾向のある小島型自己免疫症のリスクの低下と関連しています.
- これらの発見は,オメガ3脂肪酸がT1Dの発症を防ぐ潜在的な保護効果を強調しています.
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