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Updated: Jul 11, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

アンサンブルベースの受容体モデルによって発見されたMDM2-p53相互作用の小分子阻害剤

Anna L Bowman1, Zaneta Nikolovska-Coleska, Haizhen Zhong

  • 1Department of Medicinal Chemistry and the Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.

Journal of the American Chemical Society
|October 2, 2007
PubMed
まとめ

研究者らは,柔軟なタンパク質構造法を使用して,MDM2-p53の相互作用を標的とした新しい小分子阻害剤を発見しました. このアプローチは,薬剤発見におけるタンパク質-タンパク質相互作用の阻害のための強力な化合物を効率的に特定します.

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