関連する実験動画

Updated: May 5, 2026

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
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Published on: March 29, 2019

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エピジェネティックTRIMによるレトロウイルスサイレンシング

James Ellis1, Akitsu Hotta, Mojgan Rastegar

  • 1Developmental and Stem Cell Biology Program, SickKids Hospital, Toronto, Ontario, Canada. jellis@sickkids.ca

Cell
|October 10, 2007
PubMed
まとめ

胚細胞は,TRIM28コアプレッサー複合体を用いてレトロウイルスDNAを認識し,その複合体はウイルスのプライマー結合部位と結合します. この結合は,ヒストンの改変とヘテロクロマチンのタンパク質結合を通じた転写のエピジェネティックサイレンシングを開始する.

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