身体活動と心血管疾患のリスク低下:潜在的な仲介メカニズム
Samia Mora1, Nancy Cook, Julie E Buring
1Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. smora2@partners.org
Circulation
|October 31, 2007
まとめ
定期的な身体活動は,心血管疾患 (CVD) のリスクを大幅に低下させます. この利点は,主に炎症マーカーと血圧の改善によって説明され,CVD予防の重要なメカニズムを強調しています.
科学分野:
- 心血管の健康について
- 運動科学は運動科学である.
- バイオマーカー バイオマーカー
背景:
- より高い身体活動レベルは,心血管疾患 (CVD) イベントの減少と関連しています.
- この関連性の正確なメカニズムは完全に理解されていません.
- 心血管疾患のリスク要因は,仲介的な役割を果たす可能性があります.
研究 の 目的:
- 身体活動とCVDの関係における様々な危険因子の仲介的役割を調査する.
- 異なるリスク要因が観察された逆関連に与える影響を定量化する.
主な方法:
- 27,055人の健康な女性を対象に,平均10.9年の追跡期間で実施した前向きな研究.
- ヘモグロビンA1c,脂質,クレアチニン,ホモシステイン,および炎症性/静血性バイオマーカーの基準値の測定.
- 自己報告した身体活動,体重,身長,高血圧,糖尿病を評価した.
主要な成果:
- 心血管疾患のリスクは,身体活動の増加とともに線形的に減少した.
- 既知の危険因子の差異は,逆相関の59.0%を説明した.
- 炎症性/血静性バイオマーカー (32.6%) と血圧 (27.1%) は,リスク低下に最も大きく貢献した.
結論:
- 身体活動とCVDリスクの間の逆関連は,既知の危険因子によって実質的に媒介されます.
- 炎症性/静血性因子と血圧が重要な媒介因子である.
- 新規の脂質,BMI,およびヘモグロビンA1c/糖尿病も寄与したが,ホモシステインとクレアチニンは最小限の影響を及ぼした.
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