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肥満,アディポキン,腹動脈動脈瘤:男性における健康に関する研究
Jonathan Golledge1, Paula Clancy, Konrad Jamrozik
1Vascular Biology Unit, Department of Surgery, School of Medicine, James Cook University, Townsville, QLD, Australia 4811. jonathan.golledge@jcu.edu.au
Circulation
|October 31, 2007
まとめ
腰周長などの肥満の測定値は,腹動脈動脈瘤 (AAA) と関連しています. 特定のアディポキンである血清レジスティンは,AAAと大動脈直径との強い関連を示した.
科学分野:
- 血管生物学 血管生物学
- 肥満に関する研究
- エピデミオロジー エピデミオロジー
背景:
- 肥満は,閉塞性動脈疾患と関連しています.
- 肥満は伝統的に腹動脈動脈瘤 (AAA) の危険因子とは考えられていない.
研究 の 目的:
- 肥満,血清アディポキン,およびAAAの人類測定値との関連性を調査する.
- 肥満がAAAの独立した危険因子であるかどうかを判断する.
主な方法:
- 超音波を用いたAAAに対する12,203人の男性 (65歳から83歳) の集団ベースのスクリーニング.
- 心血管疾患の危険因子,腰と股関節の周りを測定する.
- 血清アディポキン濃度 (レジスティン,アディポネクチン,レプチン) は952人の男性で測定された.
主要な成果:
- 腰周長と腰から腰までの比率は,AAAと独立して関連していました.
- 血清レジスティン濃度はAAAと大動脈直径との強い独立した関連を示した.
- 血清アディポネクチンは,より小さなAAAと関連していたが,レプチンは関連性を示さなかった.
結論:
- 肥満の測定はAAAと独立して関連しています.
- 血清レジスティンは,他のアディポキンよりも,大動脈直径と強く関連しています.
- レジスティンとAAAの関連性を理解するためにさらなる研究が必要である.
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