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Updated: Jul 10, 2026

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

SUMO特異プロテアゼ1は,低酸素期におけるHIF1alphaの安定化に不可欠である

Jinke Cheng1, Xunlei Kang, Sui Zhang

  • 1Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas, Houston Health Science Center, Houston, TX 77030, USA.

Cell
|November 6, 2007
PubMed
まとめ

セントリン/SUMO特異プロテアゼ1 (SENP1) は胎児の発達に不可欠である. SENP1の喪失は,低酸素誘導因子1alpha (HIF1alpha) の安定性を破壊して貧血を引き起こし,エリトポエチン産生に影響を与えます.

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