ダークチョコは冠動脈血管運動を改善し,血小板の反応性を低下させます
Andreas J Flammer1, Frank Hermann, Isabella Sudano
1Cardiovascular Center, Cardiology, University Hospital Zurich, Raemistr 100, CH-8091 Zurich, Switzerland.
Circulation
|November 7, 2007
まとめ
フラボノイドに富んだダークチョコは,心臓移植患者の血管機能を改善し,血小板活性化を低下させた. これらの直接的な利点は,ダークチョコが移植動脈硬化症に肯定的な影響を与える可能性があることを示唆しています.
科学分野:
- 心臓病学 心臓病学
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
- 血管生物学 血管生物学
背景:
- ダークチョコレートには重要な抗酸化物質の性質があります.
- 動脈硬化,特に心臓移植では,内皮機能不全,血小板活性化,酸化ストレスに関連しています.
- フラボノイドに富んだダークチョコは,移植動脈硬化症に対する保護効果を提供することがあります.
研究 の 目的:
- 心臓移植を受けた患者の冠動脈血管および血小板機能に対するフラボノイドに富んだダークチョコレートの急性効果を調査する.
- 心血管のマーカーに対するダークチョコとカカオのない対照群の影響を比較するために.
主な方法:
- 心臓移植を受けた22人の被験者を対象とした二重盲検,ランダム化研究です.
- 定量的な冠動脈血管図と冷圧器検査を用いた冠動脈血管運動の評価.
- チョコレート摂取前後の血小板粘着と血清酸化ストレスマーカーの測定.
主要な成果:
- ダークチョコの摂取は冠動脈の直径を大幅に増加させ,内皮に依存する血管運動を改善しました.
- ダークチョコレート摂取後,血小板粘着の顕著な減少が観察されました.
- 血清酸化ストレスが低下し,エピカテキンの濃度上昇と相関していました.
結論:
- ダークチョコの摂取は,冠動脈血管拡張と血管機能の即時改善につながります.
- この研究は,黒いチョコレート摂取後に血小板の粘着と酸化ストレスが低下することを示しています.
- これらの発見は,心臓移植患者の移植動脈硬化症の管理におけるダークチョコレートの潜在的な治療的役割を示唆しています.
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