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Updated: Jul 10, 2026

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
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Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

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DUBA:タイプIインターフェロン産生を調節するデウビキチナゼ

Nobuhiko Kayagaki1, Qui Phung, Salina Chan

  • 1Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.

Science (New York, N.Y.)
|November 10, 2007
PubMed
まとめ

デウビキチン化酵素A (DUBA) は,タイプIインターフェロン (IFN-I) 産生を否定的に調節する. DUBAは,重要なシグナル伝達タンパク質であるTRAF3にユビキチン鎖を裂き,それによってパターン認識受容体 (PRRs) によって誘発される先天的な免疫反応を抑制します.

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