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Updated: Jul 10, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

サイクロプロペネスのシラ・モリタ・ベイリス・ヒルマン反応

Stepan Chuprakov1, Denis A Malyshev, Alexander Trofimov

  • 1Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, USA.

Journal of the American Chemical Society
|November 14, 2007
PubMed
まとめ

研究者らは,最初のシラ-モリタ-ベイイス-ヒルマン反応を実証し,これは新しいフォスフィン触媒プロセスである. この方法では,シリクロプロペンとカルボニル化合物を用いて,有価な1- ((シリロキシメチル) サイクロプロペンを効率的に合成します.

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Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene09:45

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Cycloaddition Reactions: MO Requirements for Thermal Activation01:16

Cycloaddition Reactions: MO Requirements for Thermal Activation

Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
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Cycloaddition Reactions: Overview

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Cycloaddition Reactions: MO Requirements for Photochemical Activation

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[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
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