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関連する概念動画

Long-term Potentiation01:35

Long-term Potentiation

51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:05

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Potentiation01:25

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
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Long-term Depression01:03

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
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Plasticity00:58

Plasticity

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Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
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Neuroplasticity01:01

Neuroplasticity

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
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Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

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皮質受容場可塑性のためのシナプス記憶の痕跡

Robert C Froemke1, Michael M Merzenich, Christoph E Schreiner

  • 1Coleman Memorial Laboratory and W. M. Keck Foundation Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143, USA. rfroemke@phy.ucsf.edu

Nature
|November 16, 2007
PubMed
まとめ
この要約は機械生成です。

塩素原核ベサリスは,一時的に抑制を軽減し,その後に興奮を起こすことで,聴覚皮質の受容領域を急速に形づくります. 学習に不可欠なこの可塑性は,何時間も持続し,永続的な記憶の痕跡を生み出します.

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Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
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Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

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Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

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関連する実験動画

Last Updated: May 2, 2026

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

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Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
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科学分野:

  • 神経科学は神経科学である.
  • 聴覚皮質 柔軟性 聴覚皮質の可塑性
  • シナプスの可塑性

背景:

  • 皮質の受容場はプラスチックで,神経の活動や経験によって変化します.
  • 神経調節は皮質の可塑性にとって不可欠ですが,皮質下系の相互作用は不明です.

研究 の 目的:

  • 大人の初等聴覚皮質 (AI) のシナプス受容場可塑性のダイナミクスを調査する.
  • 基礎核がどのように聴覚皮質回路を調節するかを理解する.

主な方法:

  • 大人の初等聴覚皮質 (AI) の体内全細胞記録.
  • 感覚刺激と核ベースアリスの活性化を組み合わせる.

主要な成果:

  • 基礎核の活性化により,シナプス阻害が数秒で急速に低下し,それに伴った刺激に特異的な興奮が続く.
  • 感受性フィールドの再編成は,短時間の基礎核刺激の後も何時間も続いた.
  • 刺激のバランスを取り戻すため,抑制はゆっくりと増加し,新しい刺激の好みを生み出しました.

結論:

  • 暫定的な無抑制期は受容場可塑性の重要なメカニズムである.
  • このプロセスは,行動的に重要な刺激のための記憶の痕跡を形成する可能性があります.