関連する実験動画

Updated: Jul 10, 2026

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
13:10

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

Published on: June 9, 2017

RNF8ユビキチンリガゼによるDNA損傷反応のオーケストレーション

Nadine K Kolas1, J Ross Chapman, Shinichiro Nakada

  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G1X5, Ontario, Canada.

Science (New York, N.Y.)
|November 17, 2007
PubMed
まとめ

ユビキチンリガゼRNF8は,DNAの二重鎖破裂修復に不可欠であり,53BP1やBRCA1.1のような重要なタンパク質の採用を媒介する. このプロセスは,MDC1のATMキナーゼ依存型リン酸化を伴い,DNA損傷反応をオーケストラ化します.

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