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社会的経済的な地位,人種/民族,および動脈硬化症の多民族研究における炎症
Nalini Ranjit1, Ana V Diez-Roux, Steven Shea
1Center for Social Epidemiology and Population Health, University of Michigan, Ann Arbor 48104, USA. nranjit@umich.edu
Circulation
|November 21, 2007
まとめ
低い社会経済的な地位は,より高い炎症と関連しており,心血管疾患のリスクを高めます. 肥満,心理的社会要因,および行動が,この関連を媒介し,人種や民族によって異なる.
科学分野:
- 心血管疾患の疫学について
- 健康の社会経済的決定要因
- 炎症と病気について
背景:
- 低社会経済的地位 (SEP) は,心血管疾患と動脈硬化症の既知のリスク因子です.
- 炎症はSEPと心血管疾患のリスクを結びつける潜在的なメカニズムですが,さらなる調査が必要です.
研究 の 目的:
- 社会経済的地位 (家庭の収入と教育) と炎症 (C反応性タンパク質とインタールイキン-6) の関連性を調査する.
- 人種と民族がこれらの関連にどのように影響するか調べる.
- 肥満,心理社会的要因,行動などの仲介要因を特定する.
主な方法:
- 多民族性動脈硬化症研究 (MESA) のベースライン試験から6814人の成年者 (45-84歳) の横断分析.
- 人種と民族の分層化された回帰分析は,SEP指標と炎症マーカーとの関連性を評価した.
- 感染症,薬物使用,心理社会的要因,行動,肥満,糖尿病などの調整が行われました.
主要な成果:
- 低所得は,すべての人種/民族集団において,より高いインタールイキン-6濃度と関連していた.
- 低教育は,白人と黒人の間でより高いインターリューキン-6レベルと関連していました.
- 肥満は,特に黒人と白人のSEP-炎症関連を説明する最も重要な要因として浮上しました.
結論:
- 家庭の収入と教育の両方が炎症と関連しており,人種/民族の違いがある.
- 肥満は,心理的社会的な要因や行動とともに,社会経済的な立場と炎症の関係を媒介する可能性があります.
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