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Updated: Jul 9, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

AMPの構造誘導設計は,高親和性と特異性を持つ果糖-1,6-双リン酸塩酵素を阻害するAMPを模倣する

Mark D Erion1, Qun Dang, M Rami Reddy

  • 1Department of Medicinal Chemistry, Metabasis Therapeutics, Inc., 11119 North Torrey Pines Road, La Jolla, California 92037, USA. erion@mbasis.com

Journal of the American Chemical Society
|November 29, 2007
PubMed
まとめ

研究者らは,グルコース産生における重要な酵素である果糖1,6-双リン酸塩酶 (FBPase) を阻害する新しいAMPミミクスを設計した. これらの強力な阻害剤はAMP結合部位を標的にし,グルコン生成を抑制することによって,2型糖尿病の潜在的な治療戦略を提供します.

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Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors

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