高トラウマ性骨折と骨のミネラル密度が低い高齢女性および男性における骨の骨折
Dawn C Mackey1, Li-Yung Lui, Peggy M Cawthon
1San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA. dmackey@sfcc-cpmc.net
JAMA
|November 29, 2007
まとめ
高トラウマの骨折は,骨のミネラル密度 (BMD) が低いことと,低トラウマの骨折に類似した将来の骨折のリスクの増加と関連しています. これらの発見は,高トラウマ骨折が骨粗鬆症の研究で考慮されるべきであることを示唆しています.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 整形外科 整形外科
- エピデミオロジー エピデミオロジー
背景:
- 高トラウマ骨折が骨粗鬆症ではないという一般的な仮定は,前向きに調査されていない.
- 骨粗鬆症は,特に高齢者集団において,重大な公衆衛生上の懸念事項である.
研究 の 目的:
- 骨のミネラル密度 (BMD) と高トラウマ骨折の関連性を調査する.
- 高トラウマ骨折が,高齢者の後の骨折のリスクを高めるかどうかを判断する.
主な方法:
- 展望的なコホート研究 (Study of Osteoporotic Fractures and Osteoporotic Fractures in Men Study) は,65歳以上のコミュニティに住む成人を対象に実施されました.
- 骨のミネラル密度 (BMD) は,二重エネルギーX線吸収計で測定され,骨折は高トラウマまたは低トラウマに分類されます.
- フォローアップ期間は,女性では9.1年,男性では5.1年でした.
主要な成果:
- 低部BMDは,女性の高トラウマ (RH1.45) と低トラウマ (RH1.49) の骨折のリスクの増加と関連しており,男性は一貫していました.
- 最初の高トラウマ骨折をした女性は,その後の骨折のリスクが34%高かった.
- 初回の低トラウマ骨折をした女性は,その後の骨折のリスクが31%高かった.
結論:
- 高トラウマ性非脊椎骨折は,高齢者の低BMDと関連しています.
- 高トラウマの骨折は,低トラウマの骨折と同様に,その後の骨折のリスクが高まっていることを示します.
- 高トラウマ骨折は,骨粗鬆症の研究および臨床試験におけるアウトカムとして考慮されるべきである.
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