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Updated: Jul 9, 2026

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

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新生タンパク質核愛好者の反応的選択による共振触媒への経路

Andrey V Reshetnyak1, Maria Francesca Armentano, Natalia A Ponomarenko

  • 1Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10, Miklukho-Maklaya str, Moscow, 117871, Russia.

Journal of the American Chemical Society
|November 30, 2007
PubMed
まとめ

この研究では,抗体断片から新しい酵素触媒を進化させるために,共性選択を用いた. 研究者らは,コヴァレンント結合を可能にする特定のチロシン残基を特定し,原始的な触媒部位を作成するための新しいアプローチを提案しました.

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