関連する実験動画

Updated: Jul 9, 2026

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
08:12

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes

Published on: November 1, 2011

DNAの管理不良は,免疫システムの監視に繋がります

Laurent Coscoy1, David H Raulet

  • 1Department of Molecular and Cell Biology and Cancer Research Laboratory, Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA. lcoscoy@berkeley.edu

Cell
|November 30, 2007
PubMed
まとめ

哺乳類のTrex1欠乏症は,DNA複製と修復における既知の役割とは対照的に,慢性的な炎症を引き起こす. この研究は,Trex1欠乏がDNA損傷のチェックポイントを活性化し,細胞質DNAの蓄積につながり,潜在的に炎症を引き起こす可能性があることを明らかにしています.

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Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

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関連する概念動画

Mismatch Repair01:36

Mismatch Repair

Overview
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
What is the Immune System?01:38

What is the Immune System?

Overview
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...