非アポプトティックな細胞死プロセスであるエントーシスは,細胞内の細胞の侵入によって発生します
Michael Overholtzer1, Arnaud A Mailleux, Ghassan Mouneimne
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Cell
|November 30, 2007
まとめ
マトリックスから切り離された上皮細胞は,一つの細胞が別の細胞に侵入する,エントーシスと呼ばれる新しい細胞死プロセスを経てます. この細胞内の細胞現象は,腫瘍抑制メカニズムである可能性があります.
科学分野:
- 細胞生物学 細胞生物学
- がん研究 がん研究
- サイトロジー サイトロジー
背景:
- 皮質細胞は通常,生存するために細胞外マトリックス (ECM) の結合を必要とし,アノイキス (アポトーシスの形態) を防ぐ.
- ECMからの脱離は,上皮細胞の細胞死経路を誘発する.
研究 の 目的:
- マトリックス分離細胞における新しい非アポプトティックな細胞死プログラムについて説明します.
- 人間の癌で観察される"細胞内の細胞"の特徴の背後にあるメカニズムを調査する.
主な方法:
- 細胞の内部化と分解過程の観察.
- 細胞内形成におけるアデレンス結合とインテグリン結合の役割の分析.
主要な成果:
- 細胞死という新しいプロセスであるエントシスを特定し,生きた細胞が隣接する細胞に侵入して内部化することを含む.
- 内部化された細胞はリソソームによって分解されるか,または放出されるかを示した.
- エントーシスをヒトがんにおける"細胞内の細胞"細胞学的特徴と結びつける証拠を提示した.
結論:
- エントーシスは,マトリックス分離細胞の非アポプトティックな細胞死メカニズムである.
- エントーシスは,インテグリン結合なしにアデレンス結合形成からの圧縮力によって駆動されます.
- エントーシスは,固有の腫瘍抑制メカニズムとして機能する可能性があります.
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