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Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...

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Preparation of Mica Supported Lipid Bilayers for High Resolution Optical Microscopy Imaging
07:48

Preparation of Mica Supported Lipid Bilayers for High Resolution Optical Microscopy Imaging

Published on: June 7, 2014

メソポラス材料における単一分子拡散の視覚化

Andreas Zürner1, Johanna Kirstein, Markus Döblinger

  • 1Department of Chemistry and Biochemistry and Center for NanoScience (CeNS), University of Munich, Butenandtstrasse 5-13 (E), D-81377 Munich, Germany.

Nature
|November 30, 2007
PubMed
まとめ
この要約は機械生成です。

研究者は,単一の染料分子がメソポラスな材料を通してどのように移動するかを視覚化しました. この電子顕微鏡と光学追跡の組み合わせは,ナノスケールの孔構造内の分子拡散ダイナミクスを明らかにします.

さらに関連する動画

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
06:34

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

Published on: September 2, 2016

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

関連する実験動画

Last Updated: Jun 26, 2026

Preparation of Mica Supported Lipid Bilayers for High Resolution Optical Microscopy Imaging
07:48

Preparation of Mica Supported Lipid Bilayers for High Resolution Optical Microscopy Imaging

Published on: June 7, 2014

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
06:34

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

Published on: September 2, 2016

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

科学分野:

  • 材料科学 材料科学とは
  • ナノテクノロジー ナノテクノロジー
  • 物理化学 物理化学

背景:

  • 周期性メソポラス材料は,さまざまな用途のために調節可能な性質を提供します.
  • これらの多孔性宿主体内の分子運動を理解することは,それらの機能にとって極めて重要です.
  • 既存の顕微鏡技術では,孔構造と分子動態を同時にイメージする能力が欠けている.

研究 の 目的:

  • メソポラス材料の複雑なナノスケールアーキテクチャ内の分子拡散を視覚化するための方法を開発.
  • メソポラスチャネルの特定の局所構造とゲスト分子の拡散行動を相関させる.
  • 構造イメージングと,多孔性の材料における動的プロセス観察の間のギャップを埋めるために.

主な方法:

  • 孔構造の詳細なマッピングのための結合伝送電子顕微鏡 (TEM).
  • シングル分子光 (SMF) トラッキングは,発光染色体分子のダイナミックな動きをモニタリングします.
  • TEMで特定された構造をSMFで観測された拡散経路とリンクするための相関顕微鏡アプローチ.

主要な成果:

  • メソポラス材料内の単一発光染料分子の拡散経路を視覚化することに成功しました.
  • 分子がナノスケールポアシステムの線形と曲線の両方をどのようにナビゲートするかを示した.
  • 観測された拡散ダイナミクスは,TEMによって特定された特定のメソポラス構造と直接相関していた.

結論:

  • TEMとSMFの組み合わせは,ナノスケールでのホスト・ゲストの相互作用に関する前例のない洞察を提供します.
  • この相関的アプローチは,多孔性の材料における分子輸送機構のより深い理解を可能にします.
  • 拡散を理解することによって,対象となるアプリケーションのためのメソポラス材料の設計と最適化のための新しい道を開きます.