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Updated: Jul 9, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
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細胞内細菌の成長は,PKB/AKT1の周りのキナーゼネットワークによって制御されます

Coenraad Kuijl1, Nigel D L Savage, Marije Marsman

  • 1Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Nature
|November 30, 2007
PubMed
まとめ

新しいキナーゼ阻害剤は,多剤耐性細菌と戦うために宿主経路を標的とする. これらのAKT1阻害剤は,細胞内病原体の増殖を阻害し,サルモネラ・タイフィムリウム (Salmonella typhimurium) やミコバクテリウム・結核 (Mycobacterium tuberculosis) などの感染症に対する新しい戦略を提供します.

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