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Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
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Rad GTPase欠乏症は,心筋縮を引き起こします

Lin Chang1, Jifeng Zhang1, Yu-Hua Tseng1

  • 1Cardiovascular Center (L.C., J.Z., C.-Q.X., T.C., S.M.D., Y.E.C.), Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich; Joslin Diabetes Center (Y.-H.T., J.I., J.C.B., C.R.K.), Harvard Medical School, Boston, Mass; Institute of Molecular Medicine (Z.S., X.Z.), Peking University, Beijing, People's Republic of China; Department of Cardiology (K.A.Y.), The Methodist Hospital Research Institute, Houston, Tex; and Cardiovascular Research Institute (Q.Y.), Morehouse School of Medicine, Atlanta, Ga.

Circulation
|December 7, 2007
PubMed
まとめ

糖尿病に関連したRas (Rad) GTPアゼは,心筋縮を阻害する. 心不全患者のRad濃度の低下と,心筋細胞とマウスのRadの操作は,カルシウムカルモジュリン依存キナーゼII (CaMKII) 経路を通じてその保護的役割を明らかにしています.

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