リンパ球差別化ホルモンのbursa of fabriciusが作られている
まとめ
チキンチムスとブルサの抽出物は,骨髄細胞の早期リンパ球分化を刺激する. 甲状腺抽出物はT細胞の発達を促進し,甲状腺抽出物はB細胞とT細胞の両方の分化を促進し,甲状腺ホルモンを示唆しています.
科学分野:
- 免疫学 免疫学とは
- 発達生物学 発達生物学とは
- 細胞生物学 細胞生物学
背景:
- リンパ球の微分化は,適応免疫にとって極めて重要です.
- リンパ球の発達におけるチムスとブルサの役割はよく知られている.
- 早期の分化シグナルを理解することは,免疫系の発達に鍵となる.
研究 の 目的:
- 鶏の骨髄における早期リンパ球分化のインビトロ誘導を調査する.
- timo と bursa の抽出物に対する特定の細胞反応を特定するために.
- これらの抽出物内の潜在的なホルモン作用を特徴づけるために.
主な方法:
- 新鮮にったニワトリから採取した骨髄細胞の分断をインビトロ培養した.
- アロアンチセラムは,新しく分化したB細胞 (Bu-1+) とT細胞 (Th-1+) を識別し,定量化するために使用されました.
- リンパ球の微分化に対するチムス抽出物とブルサル抽出物の効果を分析した.
主要な成果:
- タイマスエキスは選択的に誘発されたT細胞の分化を引き起こし,ティモポエチンに匹敵する活性を示した.
- ブルサルの抽出物はB細胞とT細胞の分化を引き起こした.
- 低濃度では,ブルサルの抽出物はB細胞の分化に優位な効果を示した.
結論:
- チキンチムスエキスには,T細胞の分化を促進する因子が含まれています.
- チキンバーサエキスは,リンパ球の差別化活性を持ち,特にB細胞の差別化活性を持っています.
- リンパ球差別化ホルモンをFabriciusのブルサから生み出す新しいホルモンを,ブルソポエチン (bursopoietin) と呼ぶことが提案されています.
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